The transmission of the incurable HIV from animals to humans may have
come about through a related virus which affects cats and which has
been around for thousands or even millions of years, according to
recent US research.
The finding has implications for scientists engaged in the creation of HIV vaccines or drugs that would fight HIV.
It
also sheds light on the way in which other viruses, such as H5N1 bird
flu, spread to humans from the animals in which they developed.
Study
author Robert Bambara, of the University of Rochester Medical Center in
New York, found a previously unnoticed stretch of viral RNA in HIV,
that closely mimics part of the human RNA strand, he and colleagues
devised a plausible explanation for why it is still there after
millions of generations.
He said that the extra RNA helps the
virus propagate itself inside the human body, and that its discovery
may suggest new ways to shut down the action of the virus using drugs.
The strand is believed to have come from the feline ancestor of the modern HIV virus.
While
HIV is believed to have jumped to humans directly from a virus found in
chimpanzees, feline immunodeficiency virus (FIV), which infects cats,
is thought to be the virus from which its chimpanzee ancestor
originated.
The researchers said that HIV-like viruses have been
identified in sheep, goats, horse, cattle and cats, but only the cat
virus FIV seems to be a close relative of HIV and simian
immunodeficiency virus (SIV).
Matthew Portnoy, of the National
Institutes of Health, said that the study had broader implications
beyond HIV research, and that it may impact responses to the current
H1N1 flu pandemic.
He said there are many cases in epidemiology where a virus jumps between species and picks up DNA from each species in turn.


