People who have problems sticking to their weight-loss regime may benefit from having their genes tested, according to a recent US study.
The researchers have found a way of looking a people's genes that seems to determine what kind of diet would benefit them most.
The three diets the researchers looked at included low-fat diets, low-carb diets, and more balanced diets.
The differences were strongest in people who were trying to follow the lowest carbohydrate and the lowest fat diets.
Where
low-carb and low-fat diets were concerned, people whose genetic
backgrounds matched their diets lost 6.8% of their body weight in the course
of the study, compared with a weight loss of just 1.4% in people whose diets did not match
their genetic predispositions.
For the purposes of the study,
the researchers looked at 140 women who were either overweight or
obese, and randomly assigned them to one of four diets.
Some of the women were put on the Atkins diet, which is based on a low carbohydrate intake.
Others
were assigned to the Ornish diet, which is extremely low in fat, or to the LEARN diet, which is also very low in
fat.
The fourth diet was the Zone diet, which focuses on balance.
The
researchers had some suppositions about which genes affect diet, and
looked for mutations in three genes, FABP2, PPARG, and ADRB2.
After
recording the amount of weight loss experienced by the women who
dieted, the researchers made DNA tests on the study subjects.
Researcher
Mindy Dopler Nelson of Stanford University said that, out of hundreds
of genes linked to obesity, fatty acid binding protein 2 (FABP2),
peroxisome proliferators activated receptor gamma (PPARG), and beta 2
adrenergic receptor (ADRB2) linked diet and weight loss.
The
researchers said that study subjects whose diets matched their genetic
predisposition lost 5.3% of their body weight on average, compared to
people whose diets were not similarly matched.
Overall, people whose diets did not match their genes experienced only a 2.3% average weight loss over the course of the study.
Researcher
Christopher Gardner of Stanford University in California said that the
potential link between diet and genetics was important in helping to
solve one of society's most pervasive problems.
Christine
Williams, a professor at the University of Reading, said that she
believed the study was very intriguing, and that it appeared to fit in well with some
of her own studies.
She said that some of her research had shown
certain genotypes were more responsive than others to certain types of
fats such as omega-3 fatty acids.


